The Cherokee Hills Byway features a variety of attractions ranging from recreational and cultural to historical and natural with a range of locations along the route. Highlights of the drive include Lake Tenkiller and the Illinois River that are carved out by blue grey flint stone, encased by towering bluffs and lined by some of the most picturesque foliage in Oklahoma. The eighty-eight mile and two-and-a-half hour byway follows Highway 10 north of Interstate 40 to U.S. Highway 412 winding through Sequoyah, Cherokee, Adair and Delaware counties. Cities and towns along the route include: Colcord, Cookson, Fort Gibson, Gore, Kansas, Park Hill, Peggs, Sallisaw, Spiro, Stilwell, Tahlequah, Vian, Wauhillau, Webbers Falls, West Siloam Springs and Westville.
Cherokee Nation continues to develop the Cherokee Hills Byway with master planning and community development, while the Oklahoma Department of Transportation and University of Oklahoma Outreach officially oversee the program. This oversight includes support for the selected roads, promoting the communities and preserving irreplaceable resources. A variety of recreational, cultural, historical, natural and scenic attractions can be found in and around the communities, some classified under multiple categories, that line the Cherokee Hills Byway.